CancerTracer: a curated database for Intrapatient Tumor Heterogeneity
●Results:
| Cancer Type | Patient Details | Trunk Mutation | Branch Mutation | Private Mutation |
|---|
| Bladder Cancer | p076_DFCI-09 | TP53(p.Y220C),CHD8(p.E477Q),NOTCH2(p.R678T) |
- |
ADNP(p.R1056C) |
| Bladder Cancer | p076_DFCI-10 | POLE(p.E2085Q),TP53(p.C176Y),IL7R(Nonstop_Mutation),EP300(p.R1974K),MAP3K1(p.S989C),EP300(p.Q1931H),ARID1A(p.Q1066) |
- |
ANK3(p.P1934Q),MSH2(p.K909N) |
| Bladder Cancer | p076_DFCI-11 | CHD8(p.E1321K),MLH1(p.Q86E),ELF3(p.F92fs) |
- |
FLG(p.R572*) |
| Bladder Cancer | p076_DFCI-12 | TP53(p.R175H),RXRA(p.S427F),ANK3(p.D3800N),MTOR(p.E2419K) |
ANK3(p.E2145K),NSD1(p.Q311*),MYD88(p.E213K),FBXW7(p.E111*) |
PIK3CA(p.M1043I),TPX2(p.K362N),PBRM1(p.M1383I) |
| Bladder Cancer | p076_DFCI-33 | CDH1(p.A709V),CDKN1A(p.D149H),CARD11(p.M417I),ARID1A(p.Q1212*),CDH1(p.Q610*),SPEN(p.R1241Q),MGA(p.S1584F),SMARCB1(p.I241fs) |
ALPK2(p.P546T),TP53(p.R280T),INTS12(p.R218T) |
RXRA(p.S427F),TPX2(p.L733V),DAXX(p.S618F),SPEN(p.Q1764H) |
| Bladder Cancer | p076_FCCC-001 | SACS(p.M4104I),POU2F2(p.S0L),PIK3CA(p.E542K),PTEN(p.S229*),TP53(p.K139N),ZNF483(p.E430K),SMARCA4(p.S662*),MGA(p.E1147K),SF3B1(p.P245A),ALPK2(p.E942*) |
- |
- |
| Bladder Cancer | p076_FCCC-004 | RHOA(p.E32Q),PRKAR1A(p.E170K),RHOA(p.E47K),CDKN2A(p.S12*),ERBB2(p.G135E),TP53(p.E285K),CREBBP(p.Y1482S),ERBB2(p.D277H) |
PLCG2(p.E357Q),ALK(p.T917K),SRSF2(p.R156P),ATM(p.S369C),INPPL1(p.R121Q) |
FLG(p.S978P),SACS(p.G4222A) |
| Bladder Cancer | p076_FCCC-008 | BRE(p.V264M),POLE(p.Q2061E),FLG(p.E1932G),TP53BP1(p.S13F),ZFHX3(p.Q1514*) |
- |
PDSS2(p.C132Y),NF1(p.R2713fs) |
| Bladder Cancer | p076_FCCC-012 | CREBBP(p.V95M),TP53(p.V173L),TRIM23(p.R563fs),CDKN1A(p.A36fs) |
- |
KIT(p.I277M),STX2(p.R197C),FLG(p.S2792L),CAP2(p.R13Q),SACS(p.S1720F),SACS(p.K3520E) |
| Bladder Cancer | p076_FCCC-014 | OTUD7A(p.A872V),HRAS(p.G13V),RHOA(p.E172Q),AXIN2(p.A417V),TP53(p.R280T) |
- |
- |
| Bladder Cancer | p076_FCCC-017 | ARID2(p.S1470L),SMARCA4(p.G1585S),SMARCA4(p.E1632K),MET(p.K303N),FLG(p.Q299K),SMARCA4(p.E1567K),MAP4K3(p.T518I),PIK3CA(p.H1047L) |
- |
PTPN11(p.S3*),BHMT2(p.E47K),SMARCA4(p.E993K),POLE(p.D16V) |
| Bladder Cancer | p076_FCCC-021 | FLG(p.Q1774*),TP53(splice_site),FAT1(p.S2033L),SIRT4(p.D86N) |
- |
- |
| Bladder Cancer | p076_FCCC-022 | SF3B1(p.E902K),SMARCA4(p.S1588C),ARID1A(p.Q944*),ARID1A(p.P885A),ARID1A(p.I908M),PIK3CA(p.Q75E),SMC3(p.S1158*),ARID1A(p.S949F),CDKN1A(p.A39fs) |
- |
SNX25(p.R704K) |
| Bladder Cancer | p076_FCCC-023 | TP53(p.E285*),NOTCH2(p.E1795K),NOTCH2(p.L775V),LCTL(p.G340R),KRAS(p.G12V) |
- |
CDC27(p.G499V),LRRC17(p.T416K),SMARCA4(p.G775S),GATA3(p.R366Q) |
| Bladder Cancer | p076_FCCC-025 | TP53(p.C277F),ECT2L(p.L218V),AZGP1(p.D55E),NFE2L2(p.E134Q),TP53(p.R156G) |
- |
JAK2(p.L474V),APC(p.E574Q),NOTCH2(p.A2018G),MTOR(p.N382K),ANK3(p.Q2220P),GNAS(p.R0Q) |
| Bladder Cancer | p076_FCCC-026 | MSH2(p.C0Y),RHOA(p.Q63H),SF3B1(p.E902G),ZNF620(p.R241W) |
ZFHX3(p.S1930F),ZFHX3(p.R2246K),SUFU(p.A14P),NOTCH1(p.E1896Q),HLA?A(splice_site),NSD1(p.S600*),ZFHX3(p.I1767M),ALK(p.T917K),ZFHX3(p.F1800L),ZFHX3(p.P1934A),CDH1(p.E463Q),ALK(p.E588K),ZFHX3(p.Q1770*),MSH6(p.L1356F) |
NSD1(p.S1454*),SPEN(p.E3593K),ELF3(VY351del),ZFHX3(p.L1481V),CTNNB1(p.H24Q),ZFHX3(p.S1519L),ERBB2(p.S310F),ARID1A(p.S614*) |
| Bladder Cancer | p076_FCCC-043 | TP53(p.G266R),CDKN2A(p.R80*),COL5A1(p.G1279S),CREBBP(p.Y1175C),PTEN(p.K6I),MSH6(p.S470*),ZNF454(p.Q345*),FLG(p.S2554L),MET(p.T625fs) |
ALPK2(p.E625*),GATA3(p.S137L),IRF4(p.R8Q),FAT1(p.P344R) |
MGA(p.G166C) |
| Bladder Cancer | p076_MSK-0101 | TP53(p.C238R),ALPK2(p.C76S),PIK3CA(p.R412Q),TP53BP1(p.N1188K),INTS12(p.E37*),JAK2(p.G1132A),FLG(p.S372C),C3orf70(p.S6L),ASXL1(p.P508A),TBC1D12(p.I560M),TP53(p.Q136*),RB1(p.V725fs) |
- |
- |
| Bladder Cancer | p076_MSK-0234 | TP53(p.E285K) |
- |
- |
| Bladder Cancer | p076_MSK-0255 | SPEN(p.Q2244H),RB1(p.L797*),SPEN(p.S324L),MEN1(p.S313L),SPEN(p.Q369*),SPEN(p.E2149K),SPEN(p.E2358K),SPEN(p.E2070K),ATP5B(p.E515A),SPEN(p.S1821N),SPEN(p.A2251P),SPEN(p.L380V),APC(p.K2399T),SPEN(p.D2145H),SPEN(p.E2016*),COL5A1(p.G849*),TP53(p.V157L),SPEN(p.E2130K),SPEN(p.E2064Q),RB1(p.L135fs) |
- |
EZH2(p.R684H) |
| Bladder Cancer | p076_MSK-0331 | ATM(p.K2643Q),KEL(p.P331S),RXRA(p.S427F),ARID1A(p.Q1425*) |
- |
ERBB3(p.H228Q),ERBB3(p.S1097P),MAP2K1(p.F53L),SPEN(p.K1496Q) |
| Bladder Cancer | p076_MSK-0373 | TP53(p.H193Y),BCAS3(p.E0K),DICER1(p.E691*),ATM(p.Q2280P),CBL(p.S899F),GATA3(p.H414L),CAP2(p.E59*),ERCC2(p.E86Q),DNER(p.C529F),NF2(p.E38E),RB1(IKQ573fs) |
- |
- |
| Bladder Cancer | p076_MSK-0439 | CD1D(p.Q332E),TP53(p.L32fs) |
- |
OR4A16(p.K22N),SPOP(p.L293R) |
| Bladder Cancer | p076_MSK-0450 | EP300(p.Q1256*) |
- |
ERBB3(p.V104L) |
| Bladder Cancer | p076_MSK-0567 | FAT1(p.Q3251*),RXRA(p.S427F),SMC3(p.S772C),PIK3CA(p.N345H),FLG(p.E651Q),TP53(p.R280T),SUFU(p.D448N),ARID1A(p.Q678E) |
- |
ATM(p.Q2243K) |
| Bladder Cancer | p076_MSK-0651 | TDRD10(p.R120W),CREBBP(p.Q2045*),TP53(p.R248P) |
- |
ERBB3(p.H228Q),PIK3R1(p.E266Q),ERBB3(p.M91I) |
| Bladder Cancer | p076_MSK-0745 | TP53(p.A161D),ARID1A(p.Q611*) |
DIAPH1(p.A1244V),GATA3(p.S140del),SACS(p.E1807K),FLG(p.S918C) |
ABL1(p.P309A),MAP2K1(p.F53L) |
| Bladder Cancer | p076_MSK-0754 | TP53(p.R213*),ANK3(p.A2006V),TET2(p.E294K) |
- |
SF3B1(p.V1147L),SLC4A5(p.G468S) |
| Bladder Cancer | p076_MSK-0760 | MAP2K1(p.F53L),CIC(p.V1072M),FAT1(p.R2556*) |
- |
TTLL9(p.V57I),GPS2(p.S301L) |
| Bladder Cancer | p076_MSK-0820 | KEAP1(p.R565T),KEAP1(p.D479H),KRAS(p.G13D),KEAP1(p.M499I),ATM(p.R2871K),SPEN(p.D2401N),ATM(p.Y2170fs) |
- |
MAP2K1(p.F53L) |
| Bladder Cancer | p084_p1 | MLL2,DICER1,CREBBP,EP300,BAP1,FGFR3(p.Y373C) |
SOS2,ERBB2(p.D277Y),DNMT1(p.C1071Y) |
PDE4DIP,NIT1,IGFN1,MSANTD4,DHCR7,TAOK3,DCP1B,DIP2B,USP15,LRRIQ1,FRY,NBEA,LRCH1,PCDH17,PAPOLA,ISLR2,RARA,USP32,GNA13,EXOC7,MED26,FPR1,TUBA3E,FARSB,SUN2,SRPRB,SGK1,ZNF292,TES,CYTH3,LMTK2,C8orf46,PREX2,CACNA1F,SRPX2,ABCC1(p.R59*) |
| Bladder Cancer | p084_p2 | CLTC,CHEK2(p.K320*),PIK3CA(p.E545K),MAP3K4,STAG2 |
TP53(p.R280T),ATRX,MLL3 |
EIF4G3,USP48,ZMYM6,CDC20,ANKRD13C,HFM1,BCAR3,MLLT10,OR5M1,TUBA1B,TSPAN19,PNN,OTOA,KRT17,SPOP,OTOP3,DNAH2,RNF213,FAM210A,MIB1,ZNF417,FIGN,PABPC1L,YTHDF1,ITSN1,MEI1,STXBP5L,TM4SF4,LEKR1,MFN1,MYRIP,CGGBP1,MINA,FNIP2,CDKN2AIP,PCDH1,PDE4D,SYNE1,RPL7L1,TDRD6,MUC17,PHKG1,CHRNB3,TNKS,SLC6A14,SPANXN1,HMGB3 |
| Bladder Cancer | p084_p3 | NCOR2,MLL2,BRCA2,SOCS1,CDH1,NF1,CDK2,CDH3,NF2,PIK3CA,TET2,EGFR(p.M567I),NOTCH1 |
FRBB2LP,TNPO1,FAT1,CSDE1 |
PRAMEF4,PDE4DIP,CELA1,ZNF761,ZNF530,FAM118A,MUC17,ESX1,GAGE2A |
| Bladder Cancer | p084_p4 | ARID1A(p.Q479*),CLSPN,NOTCH2,FIF2AK3,BMPR2,TBL1XR1(p.L11V),FBXW7(p.S546L),RASA1,AFF4,CDKN1A,ACTB,AHR,ANK3,CDKN1B,NCOR2,ZMYM2,BRCA2(p.S3131F),HSP90AA1(p.Q145*),CARM1,ERCC2,ATRX |
- |
CREBBP |
| Bladder Cancer | p101_p1 | FGFR3(missense),KDM6A(frameshift) |
SPTAN1(frameshift),CREBBP(nonsense),PIK3CA(missense) |
TP53(missense),USP28(nonsense),CREBBP(frameshift),CREBBP(splice_site) |
| Bladder Cancer | p101_p10 | KMT2A(missense),ERBB2(missense),CDKN1A(missense),GNA13(missense),RB1(nonsense),ATM(synonymous),KDM6A(nonsense),TP53(missense),PIK3CA(missense) |
- |
MB21D2(missense) |
| Bladder Cancer | p101_p2 | - |
TSC1(splice_site),RHOA(missense),FGFR3(missense),EP300(nonsense) |
- |
| Bladder Cancer | p101_p3 | - |
STAG2(nonsense),SSH3(synonymous),RBM10(nonsense),PTEN(missense),MBD1(missense),KRAS(missense),CASP8(missense),ASXL2(missense),ARID1A(missense),TP53(missense),CREBBP(missense),SPTAN1(nonsense),USP28(missense),KMT2C(frameshift) |
HIST1H3B(missense) |
| Bladder Cancer | p101_p4 | TP53(missense) |
ZBTB7B(missense),ERBB3(missense) |
KMT2D(nonsense),ATM(missense),ATM(synonymous),SPTAN1(missense),FGFR3(missense),EP300(missense) |
| Bladder Cancer | p101_p5 | SF3B1(synonymous),RB1(frameshift),CREBBP(missense),TP53(nonsense) |
- |
- |
| Bladder Cancer | p101_p6 | ATM(missense) |
GNA13(missense),FAT1(nonsense),KANSL1(missense),PARD3(missense),RXRA(synonymous) |
CREBBP(nonsense),EP300(missense),KDM6A(missense) |
| Bladder Cancer | p101_p7 | PIK3CA(missense) |
EP300(nonsense),USP28(nonsense),KMT2D(missense) |
- |
| Bladder Cancer | p101_p8 | FBXW7(missense),TP53(nonsense),KDM6A(nonsense) |
- |
PIK3CA(missense) |
| Bladder Cancer | p101_p9 | TP53(missense),PIK3CA(missense),METTL3(missense),ACTB(missense),KMT2D(nonsense),KMT2C(synonymous),CDKN1A(frameshift) |
- |
- |
